Skin Cancer and Your Genes: Melanoma Can Run in Families

Most people realize that exposure to ultraviolet radiation from the sun and tanning beds can raise the risk of skin cancer. This includes the deadliest type called melanoma.

What many people may not know is that, for some individuals, genetics can increase the risk.

At his private practice in Los Angeles, Fullerton, and Orange, California, board-certified general surgical oncologist Dr. Trevan Fischer provides state-of-the-art treatment for melanoma and other skin cancers, as well as breast cancer, gallbladder issues, and more.

He also stays abreast of the latest findings in the field through his work on clinical trials and training of surgical oncology fellows at The Angeles Clinic and Research Institute, an affiliate of Cedars-Sinai.

Melanoma

Melanoma grows in cells that produce melanin and give the skin its color. Twenty to 30% of melanomas are diagnosed in existing moles, while 70 to 80% form on skin that looks normal.

When found early and treated promptly, 99% of people survive at least five years. This is why knowing one's risks and being diligent about skin checks is critical.

The role of genetics

About nine out of 10 cases of melanoma are due to exposure to ultraviolet radiation from lifestyle factors like sun exposure and tanning beds. However, for about 10% of people, genetic factors can have an impact.

Researchers are still studying the roles of genetics in melanoma and other types of cancer, but they do know that a certain genetic change or changes can cause a predisposition. 

It's important to note that simply having a genetic predisposition does not mean cancer will definitely develop.

Clues of a genetic component

Often, people who have melanoma due to a genetic predisposition are diagnosed at younger ages. They also tend to develop multiple melanomas over the years. 

Depending on the particular gene or genes inherited, the increased lifetime risk could be anywhere from 60-90% greater in people with genetic mutations.

Those who have relatives with melanoma might assume they have a genetic risk. Still, it's also possible they shared certain behaviors with family members, like sunburns from frequent trips to the beach. 

A genetic counselor can help determine if testing makes sense depending on an individual's situation.

Detection and treatment

Regardless of having a genetic predisposition, catching melanoma early and treating it quickly leads to the best outcome. Conducting regular skin checks and seeing a healthcare professional as recommended are important steps.

If you've noticed a new or changed spot on your skin or have been diagnosed with melanoma, Dr. Fischer can help using his expert knowledge and advanced treatment protocols. Click to book an appointment or call the office today at 310-807-2688.